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News: Prescriber's Letter December 2014

Trulicity (TRUE-lih-sih-tee, dulaglutide) is another GLP-1 agonist for type 2 diabetes...after Byetta, Bydureon, Tanzeum, and Victoza.

These injectables will become more popular because they can lead to weight loss...and they rarely cause hypoglycemia.

Consider them a possible add-on to metformin...along with gliptins, glitazones, sulfonylureas, insulin, etc.

Use this table for “ballpark” comparisons...and dosing frequency.

 

GLP-1 Agonist

~ A1C Decrease

~ Weight Loss

~ Cost/month

Dosing Frequency

albiglutide (Tanzeum)

1 %

2 lbs

$330

Once WEEKLY

exenatide (Byetta)

1 %

4 lbs

$430

Twice DAILY

exenatide ER (Bydureon)

1.5 %

6 lbs

$440

Once WEEKLY

dulaglutide (Trulicity)

1.5 %

6 lbs

$500

Once WEEKLY

liraglutide (Victoza)

1.5 %

6 lbs

$400-600

Once DAILY

 

Also consider the ease of use of the different pen devices.

Bydureon and Tanzeum are likely the trickiest.  These require reconstitution by the patient or caregiver.  The others don’t need mixing.

 

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